Epic Road Trip California to Florida and back

My family and I are planning an epic road trip from California to Florida to pick up a new fishing boat. We are going to take the southern route. Sacramento - LA - Phoenix - San Antonio - Houston - Mobile - Tallahassee - Ft Lauderdale. Given this route are there interesting don't misses along the way? I would like to avoid the king and the clown as much as possible, and indulge in regional specialties where possible. This will be my first trip to the gulf region. We will be towing a BIG Boat for half the trip so please keep freeway proximity and accessibility in mind. What are the must not misses along the route?

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