Serious Eats: Talk
HFCS Causes More Weight Gain Than Sugar in Scientific Study
Obviously one study ain't an ironclad argument...but since it's not THAT hard to avoid HFC...and since sugar tastes better anyway...why mess around with it?
Rats with access to high-fructose corn syrup gained significantly more weight than those with access to table sugar, even when their overall caloric intake was the same.
"When rats are drinking high-fructose corn syrup at levels well below those in soda pop, they're becoming obese -- every single one, across the board. Even when rats are fed a high-fat diet, you don't see this; they don't all gain extra weight."